Retrospective study of renal function and hematologic indices of patients undergoing dialysis at Mistura Medical Centre, Libya

Abstract

Chronic renal disorder is one of the diseases of public health concern. Epidemiological evidence revealed that this condition's incidence and prevalence are increasing globally. Renal disease has been implicated in the disruption of normal hematological dynamics, leading to a reduction in the quality of life, higher cost of management, and increased mortality. Meanwhile, it is not clear whether this derangement in hematological parameters can be influenced by routine dialysis. This present study evaluated the retrospective hematological profile, and plasma creatinine and urea of male and female CKD patients who are undergoing dialysis. The data of hematological indices and kidney function biomarkers were obtained from patients undergoing dialysis and healthy individuals (both male and female) at the Dialysis Clinic of Mistura Medical Centre, Libya from 1st January to 31st December 2022. The data of 100 individuals were analyzed with SPSS statistical software package. P values less than 0.05 were set as statistically significant. The results revealed that there are more female patients below the age of 40 years undergoing dialysis within the study population than the number of male patients within the same age bracket. Furthermore, generally significant reductions in most of the hematological parameters in patients undergoing dialysis compared with normal male and female individuals. The levels of urea and creatinine increased significantly in both males and females undergoing dialysis compared to normal individuals. Conclusively, it is observed that the derangement of kidney function biomarkers, the hallmark of CKD is sustained coupled with the depressed hematological indices while undergoing dialysis. It will be therefore not out of place to suggest that another treatment regimen should be applied along with dialysis.